How to Start Working PRN Shifts in Missouri

May 20, 2025

If you’re a nurse in Missouri looking for flexible hours, competitive pay, and more control over your schedule, per diem nursing is exactly where you need to be. The best part? You don’t have to live in a big city like St. Louis or Kansas City. Nurses in smaller towns, like Cape Girardeau, have open PRN shifts available, and finding them doesn’t need to be difficult.

This guide will show you how to find per diem nursing shifts in Missouri quickly and easily.

What Is Per Diem Nursing?

Per diem nursing (also known as PRN) lets nurses work shifts on an as-needed basis, instead of having to commit to a full-time schedule. With per diem nursing, nurses pick up shifts based on their availability – whether that’s once a week, every day, or a few times a month. Most nurses who work PRN choose to work for a healthcare staffing agency so they have more options when it comes to open shifts.

I already wrote a deep dive into PRN nursing, so if you want to learn more, be sure to check it out.

So, to keep things on track, here are some of the key benefits I went over in that blog:

  • Higher hourly pay compared to staff roles
  • Flexibility/work-life balance
  • Opportunities across multiple healthcare facilities

Where Can You Find PRN Shifts in Missouri?

Missouri has a consistent demand for PRN nurses. Cascade Health Services started providing nurses on a PRN basis across both urban and rural areas. Here are some of the top cities we staff in Missouri:

  • St. Louis – The largest city in Missouri has a steady need for nurses across hospitals, long-term care facilities, and specialty clinics.
  • Jefferson City – As the state capital, Jefferson City offers a mix of government and private healthcare facilities.
  • Kansas City (MO) – A busy metro area with a wide variety of shift types and healthcare facilities. It’s also a great location if you want to pick up shifts in Kansas.
  • Cape Girardeau – This city offers opportunities in a small-town healthcare setting as well as more rural healthcare facilities.

Cascade Health Services connects nurses to available PRN shifts in all of these locations and more across Missouri!

How to Find Shifts Quickly

Here’s how to streamline the process and start working fast:

1. Use the Cascade Health Services App

The best way to browse open shifts is through the Cascade Health Services app. With real-time open shifts and easy-to-use filters, you can: 

  • View open shifts by facility type, unit, or location
  • Book shifts instantly
  • Receive alerts when new shifts that fit your availability become available

Prefer not to use the app? You can also talk to a team of real people through phone calls, texts, and emails. 

Tip: Make sure your Missouri nursing license is active and up to date. You can check your status through the Missouri Board of Nursing website.

Cascade Health Services open PRN shifts in Missouri

2. Complete Your Credentials

After applying and interviewing, our team will help you complete all of the necessary paperwork, like:

  • Onboarding paperwork, like federal and state documents
  • Licensing and certification verification
  • Background checks
  • Immunizations

3. Start Picking Shifts That Fit Your Life

It doesn’t matter if you want to work nights, weekends, or just a few shifts a month, per diem nursing allows you to create your own schedule. Cascade offers PRN shifts across: 

  • Hospice and palliative care
  • Hospitals
  • Long-term care and skilled nursing facilities
  • Rehabilitation centers
  • Behavioral health facilities 

Bonus Tip

One of the biggest advantages of working PRN in Missouri is flexibility across cities and regions. Some nurses choose to pick up shifts in nearby areas for variety and higher pay rates. Rural and last-minute shifts will sometimes come with premium pay, which makes them a great opportunity for nurses who are willing to drive a little further.

Ready to Get Started?

We make it easy to connect with per diem nursing shifts across Missouri. Whether you’re an RN, LPN, CNA, or CMT, there’s a facility that needs your support today.

Apply now through our job portal, or download the Cascade Health app to start browsing shifts in real-time.

What we do

Allied Healthcare & Nurse Staffing Services

Founded in 1988, Cascade Health Services is a leading healthcare and nurse staffing agency in the United States. More than 2,500 nurses, nurse aides and allied health professionals work with Cascade across the nation. We are hiring RN, LPN, LVN, CNA, CMA, CMT and other healthcare professionals for immediate Travel, Contract and PRN jobs in Nursing Homes, Long Term Care Centers, Skilled Nursing Facilities, Assisted Living, Rehabilitation Centers and Hospitals.